Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria

A new paradigm for the aetiopathology of phenylketonuria suggests the presence of amyloid-like assemblies in the brains of transgenic mouse models and patients with phenylketonuria, possibly shedding light on the selective cognitive deficit associated with this disease. Paralleling the amyloidogenic...

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Pubblicato in:Sci Rep
Autori principali: De Luigi, Ada, Mariani, Alessandro, De Paola, Massimiliano, Re Depaolini, Andrea, Colombo, Laura, Russo, Luca, Rondelli, Valeria, Brocca, Paola, Adler-Abramovich, Lihi, Gazit, Ehud, Del Favero, Elena, Cantù, Laura, Salmona, Mario
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625134/
https://ncbi.nlm.nih.gov/pubmed/26510963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15902
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