Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal. However, the rising incidence of obesity, which results in chronically elevated insulin levels, implies that insulin may also act in brain centres that regulate motivation and reward. We report here that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Stouffer, Melissa A., Woods, Catherine A., Patel, Jyoti C., Lee, Christian R., Witkovsky, Paul, Bao, Li, Machold, Robert P., Jones, Kymry T., de Vaca, Soledad Cabeza, Reith, Maarten E. A., Carr, Kenneth D., Rice, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624275/
https://ncbi.nlm.nih.gov/pubmed/26503322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9543
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