Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal. However, the rising incidence of obesity, which results in chronically elevated insulin levels, implies that insulin may also act in brain centres that regulate motivation and reward. We report here that...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Stouffer, Melissa A., Woods, Catherine A., Patel, Jyoti C., Lee, Christian R., Witkovsky, Paul, Bao, Li, Machold, Robert P., Jones, Kymry T., de Vaca, Soledad Cabeza, Reith, Maarten E. A., Carr, Kenneth D., Rice, Margaret E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624275/
https://ncbi.nlm.nih.gov/pubmed/26503322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9543
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