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The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets

To better understand how β-cells respond to proinflammatory cytokines we mapped the locations of histone 3 lysine 4 monomethylation (H3K4me1), a post-translational histone modification enriched at active and poised cis-regulatory regions, in IFNγ, Il-1β, and TNFα treated pancreatic islets. We identi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tennant, Bryan R., Hurley, Peter, Dhillon, Jasmine, Gill, Amol, Whiting, Cheryl, Hoffman, Brad G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623983/
https://ncbi.nlm.nih.gov/pubmed/26505193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141470
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