Pharmacokinetics and Tolerability of Intravenous Sildenafil in Two Subjects with Child-Turcotte-Pugh Class C Cirrhosis and Renal Dysfunction

Phosphodiesterase-5 (PDE-5) inhibitors have been used successfully in patients with cirrhosis to treat porto-pulmonary hypertension. Additionally, in cirrhosis, PDE-5 inhibitors can potentially improve portal hypertension and renal hemodynamics. No pharmacokinetics and tolerability studies of intrav...

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Pubblicato in:Dig Dis Sci
Autori principali: Mindikoglu, Ayse L., Dowling, Thomas C., Schaub, David J., Hutson, William R., Potosky, Darryn R., Christenson, Robert H., Barth, Rolf N., LaMattina, John C., Hanish, Steven I., Weir, Matthew R., Raufman, Jean-Pierre
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623880/
https://ncbi.nlm.nih.gov/pubmed/26143343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-015-3771-0
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