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Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor initiation, progression, and recurrence. To investigate the actions of metabolic regulators...

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Détails bibliographiques
Publié dans:Genes Nutr
Auteurs principaux: Montales, Maria Theresa E., Simmen, Rosalia C. M., Ferreira, Ederlan S., Neves, Valdir A., Simmen, Frank A.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623856/
https://ncbi.nlm.nih.gov/pubmed/26506839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12263-015-0499-6
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