Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs

Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) are new tools for producing gene knockout (KO) animals. The current study reports produced genetically modified pigs, in which two endogenous genes were knocked out. Porcine fibroblast cell lines were derived f...

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Publicado en:J Reprod Dev
Autores principales: MIYAGAWA, Shuji, MATSUNARI, Hitomi, WATANABE, Masahito, NAKANO, Kazuaki, UMEYAMA, Kazuhiro, SAKAI, Rieko, TAKAYANAGI, Shuko, TAKEISHI, Toki, FUKUDA, Tooru, YASHIMA, Sayaka, MAEDA, Akira, EGUCHI, Hiroshi, OKUYAMA, Hiroomi, NAGAYA, Masaki, NAGASHIMA, Hiroshi
Formato: Artigo
Lenguaje:Inglês
Publicado: The Society for Reproduction and Development 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623151/
https://ncbi.nlm.nih.gov/pubmed/26227017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1262/jrd.2015-058
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