Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo

Arginine auxotrophy constitutes a weak point of several tumors, among them glioblastoma multiforme (GBM). Hence, those tumors are supposed to be sensitive for arginine-depleting substances, such as arginine deiminase (ADI). Here we elucidated the sensitivity of patient-individual GBM cell lines towa...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Fiedler, Tomas, Strauss, Madlen, Hering, Silvio, Redanz, Ulrike, William, Doreen, Rosche, Yvonne, Classen, Carl Friedrich, Kreikemeyer, Bernd, Linnebacher, Michael, Maletzki, Claudia
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623118/
https://ncbi.nlm.nih.gov/pubmed/25774632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1026478
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