Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain

Recombinant single domain antibodies (nanobodies) constitute an attractive alternative for the production of neutralizing therapeutic agents. Their small size warrants rapid bioavailability and fast penetration to sites of toxin uptake, but also rapid renal clearance, which negatively affects their...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Rossotti, Martin A, González-Techera, Andrés, Guarnaschelli, Julio, Yim, Lucia, Camacho, Ximena, Fernández, Marcelo, Cabral, Pablo, Leizagoyen, Carmen, Chabalgoity, José A, González-Sapienza, Gualberto
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622952/
https://ncbi.nlm.nih.gov/pubmed/26192995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1068491
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