Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts

Diabetic foot ulcers (DFUs) are a serious complication of diabetes. Previous exposure to hyperglycemic conditions accelerates a decline in cellular function through metabolic memory despite normalization of glycemic control. Persistent, hyperglycemia-induced epigenetic patterns are considered a cent...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Park, Lara K, Maione, Anna G, Smith, Avi, Gerami-Naini, Behzad, Iyer, Lakshmanan K, Mooney, David J, Veves, Aristidis, Garlick, Jonathan A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622843/
https://ncbi.nlm.nih.gov/pubmed/25437049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.967584
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