Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

Daratumumab (DARA) is a human CD38-specific IgG1 antibody that is in clinical development for the treatment of multiple myeloma (MM). The potential for IgG1 antibodies to induce macrophage-mediated phagocytosis, in combination with the known presence of macrophages in the tumor microenvironment in M...

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Pubblicato in:MAbs
Autori principali: Overdijk, Marije B, Verploegen, Sandra, Bögels, Marijn, van Egmond, Marjolein, van Bueren, Jeroen J Lammerts, Mutis, Tuna, Groen, Richard WJ, Breij, Esther, Martens, Anton CM, Bleeker, Wim K, Parren, Paul WHI
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622648/
https://ncbi.nlm.nih.gov/pubmed/25760767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1007813
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