Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

Delta-like-4 ligand (DLL4) plays an important role in vascular development and is widely expressed on the vasculature of normal and tumor tissues. Anti-DLL4 is a humanized IgG1 monoclonal antibody against DLL4. The purpose of these studies was to characterize the pharmacokinetics (PK), tissue distri...

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Détails bibliographiques
Publié dans:MAbs
Auteurs principaux: Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A, Khawli, Leslie, Shen, Ben-Quan
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2014
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Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622559/
https://ncbi.nlm.nih.gov/pubmed/25484068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.36107
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