Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle

Antibody-targeted nanoparticles have the potential to significantly increase the therapeutic index of cytotoxic anti-cancer therapies by directing them to tumor cells. Using antibodies or their fragments requires careful engineering because multiple parameters, including affinity, internalization ra...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:MAbs
Päätekijät: Zhang, Kathy, Geddie, Melissa L, Kohli, Neeraj, Kornaga, Tad, Kirpotin, Dmitri B, Jiao, Yang, Rennard, Rachel, Drummond, Daryl C, Nielsen, Ulrik B, Xu, Lihui, Lugovskoy, Alexey A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2014
Aiheet:
Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622481/
https://ncbi.nlm.nih.gov/pubmed/25484041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985933
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