HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma

AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136...

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Publicado no:World J Gastroenterol
Main Authors: Lin, Jun, Deng, Chang-Sheng, Sun, Jie, Zheng, Xian-Gong, Huang, Xing, Zhou, Yan, Xiong, Ping, Wang, Ya-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2003
Assuntos:
Esophageal Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621551/
https://ncbi.nlm.nih.gov/pubmed/12632487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v9.i3.412
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spelling pubmed-46215512015-10-28 HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma Lin, Jun Deng, Chang-Sheng Sun, Jie Zheng, Xian-Gong Huang, Xing Zhou, Yan Xiong, Ping Wang, Ya-Ping World J Gastroenterol Esophageal Cancer AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics. RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs 0.1397, P = 0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles. CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma. Baishideng Publishing Group Inc 2003-03-15 2003-03-15 /pmc/articles/PMC4621551/ /pubmed/12632487 http://dx.doi.org/10.3748/wjg.v9.i3.412 Text en ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Esophageal Cancer
spellingShingle Esophageal Cancer
Lin, Jun
Deng, Chang-Sheng
Sun, Jie
Zheng, Xian-Gong
Huang, Xing
Zhou, Yan
Xiong, Ping
Wang, Ya-Ping
HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
description AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics. RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs 0.1397, P = 0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles. CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma.
author Lin, Jun
Deng, Chang-Sheng
Sun, Jie
Zheng, Xian-Gong
Huang, Xing
Zhou, Yan
Xiong, Ping
Wang, Ya-Ping
author_facet Lin, Jun
Deng, Chang-Sheng
Sun, Jie
Zheng, Xian-Gong
Huang, Xing
Zhou, Yan
Xiong, Ping
Wang, Ya-Ping
author_sort Lin, Jun
title HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
title_short HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
title_full HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
title_fullStr HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
title_full_unstemmed HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
title_sort hla-drb1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
publisher Baishideng Publishing Group Inc
container_title World J Gastroenterol
publishDate 2003
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4621551/
https://ncbi.nlm.nih.gov/pubmed/12632487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v9.i3.412
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