Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses

The interferon-induced Mx1 gene is an important part of the mammalian defense against influenza viruses. Mus musculus Mx1 inhibits influenza A virus replication and transcription by suppressing the polymerase activity of viral ribonucleoproteins (vRNPs). Here, we compared the anti-influenza virus ac...

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Bibliographic Details
Published in:J Virol
Main Authors: Verhelst, Judith, Spitaels, Jan, Nürnberger, Cindy, De Vlieger, Dorien, Ysenbaert, Tine, Staeheli, Peter, Fiers, Walter, Saelens, Xavier
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621098/
https://ncbi.nlm.nih.gov/pubmed/26292322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01744-15
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