Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15–25% in African children despite effective antimalarial chemotherapy. There are no adjunctive treatments for CM, so there is an urgent need to identify new targets for therapy. Her...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Gordon, Emile B., Hart, Geoffrey T., Tran, Tuan M., Waisberg, Michael, Akkaya, Munir, Kim, Ann S., Hamilton, Sara E., Pena, Mirna, Yazew, Takele, Qi, Chen-Feng, Lee, Chen-Fang, Lo, Ying-Chun, Miller, Louis H., Powell, Jonathan D., Pierce, Susan K.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620853/
https://ncbi.nlm.nih.gov/pubmed/26438846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516544112
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