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Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the na...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Broset, Esther, Martín, Carlos, Gonzalo-Asensio, Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620462/
https://ncbi.nlm.nih.gov/pubmed/26489860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01289-15
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