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Solid dispersions of the penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA): Formulation design and optimization studies
The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit(®) RL PO and α-tocopherol. D-optimal mix...
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| Опубликовано в: : | Pharm Dev Technol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4620067/ https://ncbi.nlm.nih.gov/pubmed/24047113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10837450.2013.836216 |
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