The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype

BACKGROUND: In breast cancer, progesterone receptor (PR) positivity or abundance is positively associated with survival and treatment response. It was initially believed that PR was a useful diagnostic marker of estrogen receptor activity, but increasingly PR has been recognised to play an important...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Need, Eleanor F., Selth, Luke A., Trotta, Andrew P., Leach, Damien A., Giorgio, Lauren, O’Loughlin, Melissa A., Smith, Eric, Gill, Peter G., Ingman, Wendy V., Graham, J. Dinny, Buchanan, Grant
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620010/
https://ncbi.nlm.nih.gov/pubmed/26498662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1819-3
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