HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse

piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult germ cells and the relative importance of piRNA methylation is poorly defined in mammals. Using a mouse model of HEN methyltransferase 1 (HENMT...

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Foilsithe in:PLoS Genet
Main Authors: Lim, Shu Ly, Qu, Zhi Peng, Kortschak, R. Daniel, Lawrence, David M., Geoghegan, Joel, Hempfling, Anna-Lena, Bergmann, Martin, Goodnow, Christopher C., Ormandy, Christopher J., Wong, Lee, Mann, Jeff, Scott, Hamish S., Jamsai, Duangporn, Adelson, David L., O’Bryan, Moira K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619860/
https://ncbi.nlm.nih.gov/pubmed/26496356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005620
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