HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse

piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult germ cells and the relative importance of piRNA methylation is poorly defined in mammals. Using a mouse model of HEN methyltransferase 1 (HENMT...

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Udgivet i:PLoS Genet
Main Authors: Lim, Shu Ly, Qu, Zhi Peng, Kortschak, R. Daniel, Lawrence, David M., Geoghegan, Joel, Hempfling, Anna-Lena, Bergmann, Martin, Goodnow, Christopher C., Ormandy, Christopher J., Wong, Lee, Mann, Jeff, Scott, Hamish S., Jamsai, Duangporn, Adelson, David L., O’Bryan, Moira K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619860/
https://ncbi.nlm.nih.gov/pubmed/26496356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005620
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