HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse

piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult germ cells and the relative importance of piRNA methylation is poorly defined in mammals. Using a mouse model of HEN methyltransferase 1 (HENMT...

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Vydáno v:PLoS Genet
Hlavní autoři: Lim, Shu Ly, Qu, Zhi Peng, Kortschak, R. Daniel, Lawrence, David M., Geoghegan, Joel, Hempfling, Anna-Lena, Bergmann, Martin, Goodnow, Christopher C., Ormandy, Christopher J., Wong, Lee, Mann, Jeff, Scott, Hamish S., Jamsai, Duangporn, Adelson, David L., O’Bryan, Moira K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619860/
https://ncbi.nlm.nih.gov/pubmed/26496356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005620
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