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Formalin Inactivation of Japanese Encephalitis Virus Vaccine Alters the Antigenicity and Immunogenicity of a Neutralization Epitope in Envelope Protein Domain III

Formalin-inactivated Japanese encephalitis virus (JEV) vaccines are widely available, but the effects of formalin inactivation on the antigenic structure of JEV and the profile of antibodies elicited after vaccination are not well understood. We used a panel of monoclonal antibodies (MAbs) to map th...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Fan, Yi-Chin, Chiu, Hsien-Chung, Chen, Li-Kuang, Chang, Gwong-Jen J., Chiou, Shyan-Song
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619746/
https://ncbi.nlm.nih.gov/pubmed/26495991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004167
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