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Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1

The homeodomain transcription factor Hoxa2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation. In this work, we dissected this non-transcriptional activity of Hoxa2 at the molecular level. The Hoxa2-mediated decay of RCHY1 involves both the 19S and...

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Bibliographic Details
Published in:PLoS One
Main Authors: Bridoux, Laure, Deneyer, Noémie, Bergiers, Isabelle, Rezsohazy, René
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619689/
https://ncbi.nlm.nih.gov/pubmed/26496426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141347
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