Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice

BACKGROUND: Stem cells of intensely regenerative tissues are susceptible to cellular damage. Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic homeostasis is sustained are not completely understood. Aging increases reactive oxy...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Porto, Marcella L., Rodrigues, Bianca P., Menezes, Thiago N., Ceschim, Sara L., Casarini, Dulce E., Gava, Agata L., Pereira, Thiago Melo C., Vasquez, Elisardo C., Campagnaro, Bianca P., Meyrelles, Silvana S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619579/
https://ncbi.nlm.nih.gov/pubmed/26498041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-015-0201-8
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