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Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents

Abundant evidence points to a key role of dopamine in motor skill learning, although the underlying cellular and molecular mechanisms are still poorly understood. Here, we used a skilled-reaching paradigm to first examine changes in the expression of the plasticity-related gene Arc to map activity i...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Qian, Yu, Forssberg, Hans, Diaz Heijtz, Rochellys
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619563/
https://ncbi.nlm.nih.gov/pubmed/26488498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140974
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