Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance

The evolution of hypermutators in response to antibiotic treatment in both clinical and laboratory settings provides a unique context for the study of adaptive evolution. With increased mutation rates, the number of hitchhiker mutations within an evolving hypermutator population is remarkably high a...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Hammerstrom, Troy G., Beabout, Kathryn, Clements, Thomas P., Saxer, Gerda, Shamoo, Yousif
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619398/
https://ncbi.nlm.nih.gov/pubmed/26488727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140489
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