Epidermal growth factor receptor status and Notch inhibition in non-small cell lung cancer cells

BACKGROUND: Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. Notch receptor undergoes cleavage by enzymes, including γ-secretase, generating the active Notch intracellular domain (NICD). The aim of the present study was to investigate the effect of DAPT, a γ-secretase...

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Dettagli Bibliografici
Pubblicato in:J Biomed Sci
Autori principali: Giannopoulou, Efstathia, Nikolakopoulos, Achilleas, Kotsirilou, Dimitra, Lampropoulou, Angeliki, Raftopoulou, Sofia, Papadimitriou, Evangelia, Theocharis, Achilleas D., Makatsoris, Thomas, Fasseas, Konstantinos, Kalofonos, Haralabos P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619334/
https://ncbi.nlm.nih.gov/pubmed/26497899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-015-0196-1
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