HER-2/neu Amplification Testing in Breast Cancer by Multiplex Ligation-Dependent Probe Amplification in Comparison with Immunohistochemistry and In Situ Hybridization

Background: Assessment of HER-2/neu status in invasive breast cancer is crucial to establish eligibility for trastuzumab and taxane based chemotherapy. Next to immunohistochemistry (IHC) to evaluate protein overexpression, a second line gene amplification test is required for cases with equivocal pr...

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Pubblicato in:Cell Oncol
Autori principali: Moelans, Cathy B., de Weger, Roel A., van Blokland, Marja T.M., Ezendam, Chantal, Elshof, Sabrina, Tilanus, Marcel G. J., van Diest, Paul J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: IOS Press 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618800/
https://ncbi.nlm.nih.gov/pubmed/19096145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CLO-2009-0461
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