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Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells

BACKGROUND: Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we add...

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Publicado en:Lipids Health Dis
Autores principales: Chen, Ying, Xu, Shu-Chang, Duan, Rui-Dong
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618740/
https://ncbi.nlm.nih.gov/pubmed/26493087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-015-0137-8
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