Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells

Trabectedin (Yondelis, ET-743) is a marine-derived tetrahydroisoquinoline alkaloid. It is originally derived from the Caribbean marine tunicate Ecteinascidia turbinata and currently produced synthetically. Trabectedin is active against a variety of tumor cell lines growing in culture. The present st...

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Publicat a:PLoS One
Autors principals: Acikgoz, Eda, Guven, Ummu, Duzagac, Fahriye, Uslu, Ruchan, Kara, Mikail, Soner, Burak Cem, Oktem, Gulperi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618065/
https://ncbi.nlm.nih.gov/pubmed/26485709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141090
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