TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replicat...

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Publicado no:Cell Rep
Main Authors: Young, Lauren M., Marzio, Antonio, Perez-Duran, Pablo, Reid, Dylan A., Meredith, Daniel N., Roberti, Domenico, Star, Ayelet, Rothenberg, Eli, Ueberheide, Beatrix, Pagano, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618055/
https://ncbi.nlm.nih.gov/pubmed/26456830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.017
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