Viruses transfer the antiviral second messenger cGAMP between cells

Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, includ...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Bridgeman, A., Maelfait, J., Davenne, T., Partridge, T., Peng, Y., Mayer, A., Dong, T., Kaever, V., Borrow, P., Rehwinkel, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617605/
https://ncbi.nlm.nih.gov/pubmed/26229117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab3632
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