The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain

Glycine transporter 1 (GlyT1) plays a crucial role in regulating extracellular glycine concentrations and might thereby constitute a new drug target for the modulation of glycinergic inhibition in pain signaling. Consistent with this view, inhibition of GlyT1 has been found to induce antinociceptive...

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Publicat a:Pain
Autors principals: Werdehausen, Robert, Mittnacht, Sebastian, Bee, Lucy A., Minett, Michael S., Armbruster, Anja, Bauer, Inge, Wood, John N., Hermanns, Henning, Eulenburg, Volker
Format: Artigo
Idioma:Inglês
Publicat: Wolters Kluwer 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617288/
https://ncbi.nlm.nih.gov/pubmed/25932687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000206
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