Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus Infectivity

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replicat...

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Udgivet i:PLoS Negl Trop Dis
Main Authors: Acharya, Dhiraj, Paul, Amber M., Anderson, John F., Huang, Faqing, Bai, Fengwei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615622/
https://ncbi.nlm.nih.gov/pubmed/26484530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004139
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