Biological impacts of “hot-spot” mutations of hepatitis B virus X proteins are genotype B and C differentiated

AIM: To investigate the biological impacts of “hot-spot” mutations on genotype B and C HBV X proteins (HBx). METHODS: Five types of “hot-spot” mutations of genotype B or C HBV X genes, which sequentially lead to the amino acid substitutions of HBx as I127T, F132Y, K130M+V131I, I127T+K130M+V131I, or...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Lin, Xu, Xu, Xiao, Huang, Qing-Ling, Liu, Yu-Qing, Zheng, Da-Li, Chen, Wan-Nan, Lin, Jian-Yin
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2005
Subjects:
Viral Hepatitis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615415/
https://ncbi.nlm.nih.gov/pubmed/16094714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i30.4703
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