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Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research

A recent paper by Deelen et al. (2014) in Human Molecular Genetics reports the largest genome-wide association study of human longevity to date. While impressive, there is a remarkable lack of association of genes known to considerably extend lifespan in rodents with human longevity, both in this la...

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Vydáno v:Cell Cycle
Hlavní autor: de Magalhães, João Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614541/
https://ncbi.nlm.nih.gov/pubmed/25486354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.950151
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