Eribulin disrupts EB1-microtubule plus-tip complex formation

Eribulin mesylate is a synthetic analog of halichondrin B known to bind tubulin and microtubules, specifically at their protein rich plus-ends, thereby dampening microtubule (MT) dynamics, arresting cells in mitosis, and inducing apoptosis. The proteins which bind to the MT plus-end are known as mic...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: O’Rourke, Brian, Yang, Chia-Ping Huang, Sharp, David, Horwitz, Susan Band
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614316/
https://ncbi.nlm.nih.gov/pubmed/25485501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.950143
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