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Eribulin disrupts EB1-microtubule plus-tip complex formation
Eribulin mesylate is a synthetic analog of halichondrin B known to bind tubulin and microtubules, specifically at their protein rich plus-ends, thereby dampening microtubule (MT) dynamics, arresting cells in mitosis, and inducing apoptosis. The proteins which bind to the MT plus-end are known as mic...
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| I publikationen: | Cell Cycle |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Taylor & Francis
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4614316/ https://ncbi.nlm.nih.gov/pubmed/25485501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.950143 |
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