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Targeting multiple tyrosine kinase receptors with Dovitinib blocks invasion and the interaction between tumor cells and cancer-associated fibroblasts in breast cancer

A constitutive and dynamic interaction between tumor cells and their surrounding stroma is a prerequisite for tumor invasion and metastasis. Fibroblasts and myofibroblasts (collectively called cancer associated fibroblasts, CAFs) often represent the major cellular components of tumor stroma. Tumor c...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Zang, Chuanbing, Eucker, Jan, Habbel, Piet, Neumann, Christian, Schulz, Carsten-Oliver, Bangemann, Nikola, Kissner, Lutz, Riess, Hanno, Liu, Hongyu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614007/
https://ncbi.nlm.nih.gov/pubmed/25714853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.995050
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