Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

Insulin receptors (IRs) are expressed in discrete neuronal populations in the central nervous system, including the hippocampus. To elucidate the functional role of hippocampal IRs independent of metabolic function, we generated a model of hippocampal-specific insulin resistance using a lentiviral v...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Diabetes
Prif Awduron: Grillo, Claudia A., Piroli, Gerardo G., Lawrence, Robert C., Wrighten, Shayna A., Green, Adrienne J., Wilson, Steven P., Sakai, Randall R., Kelly, Sandra J., Wilson, Marlene A., Mott, David D., Reagan, Lawrence P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2015
Pynciau:
Complications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613975/
https://ncbi.nlm.nih.gov/pubmed/26216852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0596
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