In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice

P-glycoprotein (Pgp) [the product of the MDR1 (ABCB1) gene] at the blood-brain barrier (BBB) limits central nervous system (CNS) entry of many prescribed drugs, contributing to the poor success rate of CNS drug candidates. Modulating Pgp expression could improve drug delivery into the brain; however...

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Publicado no:Drug Metab Dispos
Main Authors: Yasuda, Kazuto, Cline, Cynthia, Lin, Yvonne S., Scheib, Rachel, Ganguly, Samit, Thirumaran, Ranjit K., Chaudhry, Amarjit, Kim, Richard B., Schuetz, Erin G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613952/
https://ncbi.nlm.nih.gov/pubmed/26281846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065078
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