Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production. A Gateway to Pulmonary Arterial Hypertension

Rationale: Mutations in bone morphogenetic protein receptor type II (BMPR-II) underlie most cases of heritable pulmonary arterial hypertension (PAH). However, disease penetrance is only 20–30%, suggesting a requirement for additional triggers. Inflammation is emerging as a key disease-related factor...

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Опубликовано в: :Am J Respir Crit Care Med
Главные авторы: Soon, Elaine, Crosby, Alexi, Southwood, Mark, Yang, Peiran, Tajsic, Tamara, Toshner, Mark, Appleby, Sarah, Shanahan, Catherine M., Bloch, Kenneth D., Pepke-Zaba, Joanna, Upton, Paul, Morrell, Nicholas W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2015
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613895/
https://ncbi.nlm.nih.gov/pubmed/26073741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201408-1509OC
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