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Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
Somatic cells senesce in culture after a finite number of divisions indefinitely arresting their proliferation. DNA damage and senescence increase the cellular number of centrosomes, the 2 microtubule organizing centers that ensure bipolar mitotic spindles. Centrosomes also provide the basal body fr...
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| Publicado no: | Cell Cycle |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613152/ https://ncbi.nlm.nih.gov/pubmed/25486364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2015.945868 |
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