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Regulation of Greatwall kinase by protein stabilization and nuclear localization

Greatwall (Gwl) functions as an essential mitotic kinase by antagonizing protein phosphatase 2A. In this study we identified Hsp90, Cdc37 and members of the importin α and β families as the major binding partners of Gwl. Both Hsp90/Cdc37 chaperone and importin complexes associated with the N-termina...

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Publicat a:Cell Cycle
Autors principals: Yamamoto, Tomomi M, Wang, Ling, Fisher, Laura A, Eckerdt, Frank D, Peng, Aimin
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612739/
https://ncbi.nlm.nih.gov/pubmed/25483093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.962942
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