Macrophages Reprogrammed In Vitro Towards the M1 Phenotype and Activated with LPS Extend Lifespan of Mice with Ehrlich Ascites Carcinoma

BACKGROUND: The majority of tumors trigger macrophage reprogramming from an anti-tumor M1 phenotype towards a pro-tumor M2 phenotype. The M2 phenotype promotes tumor growth. We hypothesized that increasing the number of M1 macrophages in a tumor would limit carcinogenesis and extend the lifespan of...

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Bibliografiska uppgifter
I publikationen:Med Sci Monit Basic Res
Huvudupphovsmän: Kalish, Sergey V., Lyamina, Svetlana V., Usanova, Elena A., Manukhina, Eugenia B., Larionov, Nikolai P., Malyshev, Igor Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Scientific Literature, Inc. 2015
Ämnen:
Molecular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612464/
https://ncbi.nlm.nih.gov/pubmed/26471744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSMBR.895563
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