CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

BACKGROUND: Disruptive mutation in the CHD8 gene is one of the top genetic risk factors in autism spectrum disorders (ASDs). Previous analyses of genome-wide CHD8 occupancy and reduced expression of CHD8 by shRNA knockdown in committed neural cells showed that CHD8 regulates multiple cell processes...

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Detalhes bibliográficos
Publicado no:Mol Autism
Main Authors: Wang, Ping, Lin, Mingyan, Pedrosa, Erika, Hrabovsky, Anastasia, Zhang, Zheng, Guo, Wenjun, Lachman, Herbert M., Zheng, Deyou
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612430/
https://ncbi.nlm.nih.gov/pubmed/26491539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-015-0048-6
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