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High thermodynamic stability of parametrically designed helical bundles
We describe a procedure for designing proteins with backbones produced by varying the parameters in the Crick coiled coil–generating equations. Combinatorial design calculations identify low-energy sequences for alternative helix supercoil arrangements, and the helices in the lowest-energy arrangeme...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612401/ https://ncbi.nlm.nih.gov/pubmed/25342806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257481 |
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