Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways

Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies, characterized by the local invasion into surrounding tissues and early metastasis to distant organs. Oncogenic mutations of the K-RAS gene occur in more than 90% of human pancreatic cancers. The goal of this study was to in...

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Detalhes bibliográficos
Publicado no:Cancer Growth Metastasis
Main Authors: Padavano, Julianna, Henkhaus, Rebecca S, Chen, Hwudaurw, Skovan, Bethany A, Cui, Haiyan, Ignatenko, Natalia A
Formato: Artigo
Idioma:Inglês
Publicado em: Libertas Academica 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612127/
https://ncbi.nlm.nih.gov/pubmed/26512205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/CGM.S29407
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