Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression

Deregulation of STAT signaling has been implicated in the pathogenesis for a variety of cancers, including CTCL. Constitutive activation of STAT5 and STAT3 was observed in early and late stages of CTCL, respectively. In early stages, IL-2, IL-7 and IL-15 signaling via JAK1 and JAK3 kinases is believ...

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發表在:Cell Cycle
Main Authors: Netchiporouk, Elena, Litvinov, Ivan V, Moreau, Linda, Gilbert, Martin, Sasseville, Denis, Duvic, Madeleine
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2014
主題:
Perspectives
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612117/
https://ncbi.nlm.nih.gov/pubmed/25485578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.965061
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