Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system

Cyclic AMP/protein kinase A (cAMP/PKA) and glucocorticoids promote the death of many cell types, including cells of hematopoietic origin. In wild-type (WT) S49 T-lymphoma cells, signaling by cAMP and glucocorticoids converges on the induction of the proapoptotic B-cell lymphoma-family protein Bim to...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Keshwani, Malik M., Kanter, Joan R., Ma, Yuliang, Wilderman, Andrea, Darshi, Manjula, Insel, Paul A., Taylor, Susan S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611605/
https://ncbi.nlm.nih.gov/pubmed/26417071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516057112
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