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Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1

In this study we show that binding of mitochondria to vimentin intermediate filaments (VIF) is regulated by GTPase Rac1. The activation of Rac1 leads to a redoubling of mitochondrial motility in murine fibroblasts. Using double-mutants Rac1(G12V, F37L) and Rac1(G12V, Y40H) that are capable to activa...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Matveeva, Elena A., Venkova, Larisa S., Chernoivanenko, Ivan S., Minin, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610213/
https://ncbi.nlm.nih.gov/pubmed/26369929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.011874
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